Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains

We previously reported that mouse strains with lower circulating insulin-like growth factor 1 (IGF1) level at 6 mo have significantly extended longevity. Here we report that strains with lower IGF1 have significantly delayed age of female sexual maturation, measured by vaginal patency (VP). Among st...

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Bibliografiske detaljer
Main Authors: Yuan, Rong, Meng, Qingying, Nautiyal, Jaya, Flurkey, Kevin, Tsaih, Shirng-Wern, Krier, Rebecca, Parker, Malcolm G., Harrison, David E., Paigen, Beverly
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361401/
https://ncbi.nlm.nih.gov/pubmed/22566614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121113109
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