Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ × SM/J intercross

A higher incidence of coronary artery disease is associated with a lower level of HDL-cholesterol. We searched for genetic loci influencing HDL-cholesterol in F2 mice from a cross between MRL/MpJ and SM/J mice. Quantitative trait loci (QTL) mapping revealed one significant HDL QTL (Apoa2 locus), fou...

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Hlavní autoři: Leduc, Magalie S., Blair, Rachael Hageman, Verdugo, Ricardo A., Tsaih, Shirng-Wern, Walsh, Kenneth, Churchill, Gary A., Paigen, Beverly
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2012
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351823/
https://ncbi.nlm.nih.gov/pubmed/22498810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M025833
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