Osteopontin is Induced by Hedgehog Pathway Activation and Promotes Fibrosis Progression in Nonalcoholic Steatohepatitis

BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis. Recently, we showed that NASH-related cirrhosis is associated with Hedgehog (Hh) pathway activation. The gene encoding Osteopontin (OPN), a pro-fibrogenic extracellular matrix protein and cytokine, is a direct transcrip...

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Autors principals: Syn, Wing-Kin, Choi, Steve S, Liaskou, Evaggelia, Karaca, Gamze F, Agboola, Kolade M, Oo, Ye Htun, Mi, Zhiyong, Pereira, Thiago A, Zdanowicz, Marzena, Malladi, Padmini, Chen, Yuping, Moylan, Cynthia, Jung, Youngmi, Bhattacharya, Syamal D., Teaberry, Vanessa, Omenetti, A, Abdelmalek, Manal F., Guy, Cynthia D, Adams, David H, Kuo, Paul C, Michelotti, Gregory A, Whitington, Peter F, Diehl, Anna Mae
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025083/
https://ncbi.nlm.nih.gov/pubmed/20967826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23998
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