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Reconstructing a Chloride-binding Site in a Bacterial Neurotransmitter Transporter Homologue
In ion-coupled transport proteins, occupation of selective ion-binding sites is required to trigger conformational changes that lead to substrate translocation. Neurotransmitter transporters, targets of abused and therapeutic drugs, require Na(+) and Cl(−) for function. We recently proposed a chlori...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024779/ https://ncbi.nlm.nih.gov/pubmed/21115480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.186064 |
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