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Reconstructing a Chloride-binding Site in a Bacterial Neurotransmitter Transporter Homologue

In ion-coupled transport proteins, occupation of selective ion-binding sites is required to trigger conformational changes that lead to substrate translocation. Neurotransmitter transporters, targets of abused and therapeutic drugs, require Na(+) and Cl(−) for function. We recently proposed a chlori...

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主要な著者: Tavoulari, Sotiria, Rizwan, Ahsan N., Forrest, Lucy R., Rudnick, Gary
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024779/
https://ncbi.nlm.nih.gov/pubmed/21115480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.186064
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