Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

Malignant astrocytoma, the most prevalent primary brain tumor, is resistant to all known therapies and frequently harbors mutations that inactivate p53 and activate Ras signaling. We have generated mouse strains that lack p53 and harbor a conditional allele of the NF1 tumor suppressor that negativel...

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Bibliographic Details
Main Authors: Zhu, Yuan, Guignard, Frantz, Zhao, Dawen, Liu, Li, Burns, Dennis K., Mason, Ralph P., Messing, Albee, Parada, Luis F.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024718/
https://ncbi.nlm.nih.gov/pubmed/16098465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2005.07.004
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