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Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
Malignant astrocytoma, the most prevalent primary brain tumor, is resistant to all known therapies and frequently harbors mutations that inactivate p53 and activate Ras signaling. We have generated mouse strains that lack p53 and harbor a conditional allele of the NF1 tumor suppressor that negativel...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024718/ https://ncbi.nlm.nih.gov/pubmed/16098465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2005.07.004 |
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