Astrocyte-Specific Inactivation of the Neurofibromatosis 1 Gene (NF1) Is Insufficient for Astrocytoma Formation

Individuals with the neurofibromatosis 1 (NF1) inherited tumor syndrome develop low-grade gliomas (astrocytomas) at an increased frequency, suggesting that the NF1 gene is a critical growth regulator for astrocytes. In an effort to determine the contribution of the NF1 gene product, neurofibromin, t...

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Main Authors: Bajenaru, Michaela Livia, Zhu, Yuan, Hedrick, Nicolé M., Donahoe, Jessica, Parada, Luis F., Gutmann, David H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC139771/
https://ncbi.nlm.nih.gov/pubmed/12077339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.14.5100-5113.2002
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