Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

Malignant astrocytomas are infiltrative and incurable brain tumors. Despite profound therapeutic implications, the identity of the cell(s) of origin has not been rigorously determined. We previously reported mouse models based on conditional inactivation of human astrocytoma-relevant tumor suppresso...

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Main Authors: Alcantara Llaguno, Sheila, Chen, Jian, Kwon, Chang-Hyuk, Jackson, Erica L., Li, Yanjiao, Burns, Dennis K., Alvarez-Buylla, Arturo, Parada, Luis F.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650425/
https://ncbi.nlm.nih.gov/pubmed/19111880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.12.006
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