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MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway

The MUC1 oncoprotein interacts with the c-Abl tyrosine kinase and blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. Mutation of the MUC1 cytoplasmic domain at Tyr-60 disrupts the MUC1-c-Abl interaction. The present results demonstrate that the MUC1(Y60F) mutant is a potent i...

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Bibliografiske detaljer
Main Authors: Raina, Deepak, Ahmad, Rehan, Chen, Dongshu, Kumar, Shailendra, Kharbanda, Surender, Kufe, Donald
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023907/
https://ncbi.nlm.nih.gov/pubmed/18981727
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