Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog, γ-tocotrienol: evidence of a role for tetrahydrobiopterin

PURPOSE: The vitamin E analog γ-tocotrienol (GT3) is a powerful radioprotector. GT3 reduces post-radiation vascular peroxynitrite production, an effect dependent on inhibition of hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase. HMG-CoA reductase inhibitors mediate their pleiotropic effects vi...

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Bibliographische Detailangaben
Hauptverfasser: Berbee, Maaike, Fu, Qiang, Boerma, Marjan, Pathak, Rupak, Zhou, Daohong, Kumar, K. Sree, Hauer-Jensen, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023840/
https://ncbi.nlm.nih.gov/pubmed/20950957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2010.08.032
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