The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage

PURPOSE: Ionizing radiation (IR) generates reactive oxygen species (ROS), which cause DNA double-strand breaks (DSBs) that are responsible for cytogenetic alterations. Because antioxidants are potent ROS scavengers, we determined whether the vitamin E isoform γ-tocotrienol (GT3), a radio-protective...

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Enregistré dans:
Détails bibliographiques
Publié dans:Pharm Res
Auteurs principaux: Pathak, Rupak, Bachri, Abdel, Ghosh, Sanchita P., Koturbash, Igor, Boerma, Marjan, Binz, Regina K., Sawyer, Jeffrey R., Hauer-Jensen, Martin
Format: Artigo
Langue:Inglês
Publié: Springer US 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967083/
https://ncbi.nlm.nih.gov/pubmed/27216753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-1950-0
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