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Danthron Functions as a Retinoic X Receptor Antagonist by Stabilizing Tetramers of the Receptor
Retinoic X receptor (RXR) is a promising target for drug discovery against cancer and metabolic syndromes. Here, we identified a specific RXRα antagonist, danthron, from the traditional Chinese medicine rhubarb. Danthron repressed all tested RXRα-involved response element transcription, including th...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023482/ https://ncbi.nlm.nih.gov/pubmed/21084305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166215 |
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