Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor

Farnesoid X receptor α (FXRα) as a bile acid sensor plays potent roles in multiple metabolic processes, and its antagonist has recently revealed special interests in the treatment of metabolic disorders, although the underlying mechanisms still remain unclear. Here, we identified that the small mole...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Xu, Xing, Xu, Xin, Liu, Peng, Zhu, Zhi-yuan, Chen, Jing, Fu, Hai-an, Chen, Li-li, Hu, Li-hong, Shen, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528148/
https://ncbi.nlm.nih.gov/pubmed/26100621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630475
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