Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor

Farnesoid X receptor α (FXRα) as a bile acid sensor plays potent roles in multiple metabolic processes, and its antagonist has recently revealed special interests in the treatment of metabolic disorders, although the underlying mechanisms still remain unclear. Here, we identified that the small mole...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Xu, Xing, Xu, Xin, Liu, Peng, Zhu, Zhi-yuan, Chen, Jing, Fu, Hai-an, Chen, Li-li, Hu, Li-hong, Shen, Xu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528148/
https://ncbi.nlm.nih.gov/pubmed/26100621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630475
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