Danthron Functions as a Retinoic X Receptor Antagonist by Stabilizing Tetramers of the Receptor

Retinoic X receptor (RXR) is a promising target for drug discovery against cancer and metabolic syndromes. Here, we identified a specific RXRα antagonist, danthron, from the traditional Chinese medicine rhubarb. Danthron repressed all tested RXRα-involved response element transcription, including th...

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Bibliografiske detaljer
Main Authors: Zhang, Haitao, Zhou, Rong, Li, Li, Chen, Jing, Chen, Lili, Li, Chenjing, Ding, Hong, Yu, Liang, Hu, Lihong, Jiang, Hualiang, Shen, Xu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023482/
https://ncbi.nlm.nih.gov/pubmed/21084305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166215
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