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mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic kidney disease

Rapamycin slows disease progression in the male Han:SPRD (Cy/+) rat with polycystic kidney disease (PKD). The aim of this study was to determine the effect of rapamycin on PKD and the relative contributions of the proproliferative mammalian target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2) i...

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Detalles Bibliográficos
Main Authors: Belibi, Franck, Ravichandran, Kameswaran, Zafar, Iram, He, Zhibin, Edelstein, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023230/
https://ncbi.nlm.nih.gov/pubmed/20943770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00129.2010
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