Mst1 and Mst2 maintain hepatocyte quiescence and suppress the development of hepatocellular carcinoma through inactivation of the Yap1 oncogene

Hippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in Drosophila. We show that the Mst1 and Mst2 protein kinases, the mammalian Hippo orthologs, are cleaved and constitutively activated in the mouse liver. Combined Mst1/2 deficiency in the liver results in loss of inhibitory S...

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Main Authors: Zhou, Dawang, Conrad, Claudius, Xia, Fan, Park, Ji-Sun, Payer, Bernhard, Yin, Yi, Lauwers, Gregory Y., Thasler, Wolfgang, Lee, Jeannie T., Avruch, Joseph, Bardeesy, Nabeel
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023165/
https://ncbi.nlm.nih.gov/pubmed/19878874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.09.026
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