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Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid–base catalysis? A critical assessment of available experimental data

The active centers of the hairpin and VS ribozymes are both generated by the interaction of two internal loops, and both ribozymes use guanine and adenine nucleobases to accelerate cleavage and ligation reactions. The centers are topologically equivalent and the relative positioning of key elements...

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Библиографические подробности
Главные авторы: Wilson, Timothy J., Lilley, David M.J.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022271/
https://ncbi.nlm.nih.gov/pubmed/21173201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2473711
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