Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High-Throughput Screening

A simple steady-state kinetic high-throughput assay was developed for the salicylate synthase MbtI from Mycobacterium tuberculosis, which catalyzes the first committed step of mycobactin biosynthesis. The mycobactins are small-molecule iron chelators produced by M. tuberculosis, and their biosynthes...

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Autores principales: Vasan, Mahalakshmi, Neres, João, Williams, Jessica, Wilson, Daniel J., Teitelbaum, Aaron M., Remmel, Rory P., Aldrich, Courtney C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021963/
https://ncbi.nlm.nih.gov/pubmed/21053346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000275
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