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Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High-Throughput Screening

A simple steady-state kinetic high-throughput assay was developed for the salicylate synthase MbtI from Mycobacterium tuberculosis, which catalyzes the first committed step of mycobactin biosynthesis. The mycobactins are small-molecule iron chelators produced by M. tuberculosis, and their biosynthes...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Vasan, Mahalakshmi, Neres, João, Williams, Jessica, Wilson, Daniel J., Teitelbaum, Aaron M., Remmel, Rory P., Aldrich, Courtney C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021963/
https://ncbi.nlm.nih.gov/pubmed/21053346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000275
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