Assaying Pharmacodynamic Endpoints with Targeted Therapy: Flavopiridol and 17AAG Induced Dephosphorylation of Histone H1.5 in Acute Myeloid Leukemia

Histone H1 is commonly used to assay kinase activity in vitro. As many promising targeted therapies affect kinase activity of specific enzymes involved in cancer transformation, H1 phosphorylation can serve as potential pharmacodynamic marker for drug activity within the cell. In this report we util...

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Detalhes bibliográficos
Main Authors: Wang, Liwen, Harshman, Sean W., Liu, Shujun, Ren, Chen, Xu, Hua, Sallans, Larry, Grever, Michael, Byrd, John C., Marcucci, Guido, Freitas, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021470/
https://ncbi.nlm.nih.gov/pubmed/21110323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201000080
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