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E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo
Mutational inactivation of the RB1 tumor suppressor gene initiates retinoblastoma and other human cancers. RB1 protein (pRb) restrains cell proliferation by binding E2f transcription factors and repressing the expression of cell cycle target genes. It is presumed that loss of pRb/E2f interaction acc...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021049/ https://ncbi.nlm.nih.gov/pubmed/21187395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015027108 |
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