E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo

Mutational inactivation of the RB1 tumor suppressor gene initiates retinoblastoma and other human cancers. RB1 protein (pRb) restrains cell proliferation by binding E2f transcription factors and repressing the expression of cell cycle target genes. It is presumed that loss of pRb/E2f interaction acc...

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Bibliografiske detaljer
Main Authors: Sun, Huifang, Wang, Yanqing, Chinnam, Meenalakshmi, Zhang, Xiaojing, Hayward, Simon W., Foster, Barbara A., Nikitin, Alexander Y., Wills, Marcia, Goodrich, David W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021049/
https://ncbi.nlm.nih.gov/pubmed/21187395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015027108
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