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Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysis
Urokinase-type plasminogen activator (uPA) is a potent catalyst of extracellular proteolysis, which also binds to a high-affinity plasma membrane receptor (uPAR). Binding of uPA may influence pericellular proteolysis and/or activate intracellular signal transduction. Transgenic mice overexpressing e...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2000
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC302082/ https://ncbi.nlm.nih.gov/pubmed/10970872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.17.4817 |
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