Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

Histone deacetylase (HDAC) inhibitors induce cell cycle arrest, differentiation or apoptosis in tumour cells and are, therefore, promising anti-cancer reagents. However, the specific HDAC isoforms that mediate these effects are not yet identified. To explore the role of HDAC1 in tumourigenesis and t...

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Hauptverfasser: Lagger, Sabine, Meunier, Dominique, Mikula, Mario, Brunmeir, Reinhard, Schlederer, Michaela, Artaker, Matthias, Pusch, Oliver, Egger, Gerda, Hagelkruys, Astrid, Mikulits, Wolfgang, Weitzer, Georg, Muellner, Ernst W, Susani, Martin, Kenner, Lukas, Seiser, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020644/
https://ncbi.nlm.nih.gov/pubmed/20967026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.264
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