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Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping
Essential telomere ‘capping' proteins act as a safeguard against ageing and cancer by inhibiting the DNA damage response (DDR) and regulating telomerase recruitment, thus distinguishing telomeres from double-strand breaks (DSBs). Uncapped telomeres and unrepaired DSBs can both stimulate a poten...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3020640/ https://ncbi.nlm.nih.gov/pubmed/21045806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.267 |
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