Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

Exo1 is a nuclease involved in mismatch repair, DSB repair, stalled replication fork processing and in the DNA damage response triggered by dysfunctional telomeres. In budding yeast and mice, Exo1 creates single-stranded DNA (ssDNA) at uncapped telomeres. This ssDNA accumulation activates the checkp...

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Hlavní autoři: Morin, Isabelle, Ngo, Hien-Ping, Greenall, Amanda, Zubko, Mikhajlo K, Morrice, Nick, Lydall, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532783/
https://ncbi.nlm.nih.gov/pubmed/18756267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.171
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