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Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
Exo1 is a nuclease involved in mismatch repair, DSB repair, stalled replication fork processing and in the DNA damage response triggered by dysfunctional telomeres. In budding yeast and mice, Exo1 creates single-stranded DNA (ssDNA) at uncapped telomeres. This ssDNA accumulation activates the checkp...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2532783/ https://ncbi.nlm.nih.gov/pubmed/18756267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.171 |
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