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Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs

Acetylation of a transcription factor has recently been shown to play a significant role in gene regulation. Here we show that GATA-3 is acetylated in T cells and that a mutation introduced into amino acids 305–307 (KRR-GATA3) creates local hypoacetylation in GATA-3. Remarkably, KRR-GATA3 possesses...

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Udgivet i:EMBO J
Principais autores: Yamagata, Tetsuya, Mitani, Kinuko, Oda, Hideaki, Suzuki, Takahiro, Honda, Hiroaki, Asai, Takashi, Maki, Kazuhiro, Nakamoto, Tetsuya, Hirai, Hisamaru
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302063/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10970860/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.17.4676
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