Association of Insulin Receptor Substrate Proteins with Bcl-2 and Their Effects on Its Phosphorylation and Antiapoptotic Function

Insulin receptor substrate (IRS) proteins are docking proteins that couple growth factor receptors to various effector molecules, including phosphoinositide-3 kinase, Grb-2, Syp, and Nck. Here we show that IRS-1 associates with the loop domain of Bcl-2 and synergistically up-regulates antiapoptotic...

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Hauptverfasser: Ueno, Hiroo, Kondo, Eisaku, Yamamoto-Honda, Ritsuko, Tobe, Kazuyuki, Nakamoto, Tetsuya, Sasaki, Ko, Mitani, Kinuko, Furusaka, Akihiro, Tanaka, Teruji, Tsujimoto, Yoshihide, Kadowaki, Takashi, Hirai, Hisamaru
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC14806/
https://ncbi.nlm.nih.gov/pubmed/10679027
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