Association of Insulin Receptor Substrate Proteins with Bcl-2 and Their Effects on Its Phosphorylation and Antiapoptotic Function

Insulin receptor substrate (IRS) proteins are docking proteins that couple growth factor receptors to various effector molecules, including phosphoinositide-3 kinase, Grb-2, Syp, and Nck. Here we show that IRS-1 associates with the loop domain of Bcl-2 and synergistically up-regulates antiapoptotic...

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Publicado en:	Mol Biol Cell
Autores principales:	Ueno, Hiroo, Kondo, Eisaku, Yamamoto-Honda, Ritsuko, Tobe, Kazuyuki, Nakamoto, Tetsuya, Sasaki, Ko, Mitani, Kinuko, Furusaka, Akihiro, Tanaka, Teruji, Tsujimoto, Yoshihide, Kadowaki, Takashi, Hirai, Hisamaru
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Cell Biology 2000
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14806/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10679027/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.11.2.735
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