Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs
Acetylation of a transcription factor has recently been shown to play a significant role in gene regulation. Here we show that GATA-3 is acetylated in T cells and that a mutation introduced into amino acids 305–307 (KRR-GATA3) creates local hypoacetylation in GATA-3. Remarkably, KRR-GATA3 possesses...
Kaydedildi:
| Yayımlandı: | EMBO J |
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| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2000
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302063/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10970860/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.17.4676 |
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