RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I

The rapid induction of type I interferon (IFN) is essential for establishing innate antiviral responses. During infection, cytoplasmic viral RNA is sensed by two DExD/H box RNA helicases, RIG-I and MDA5, ultimately driving IFN production. Here, we demonstrate that purified genomic RNA from HIV-1 ind...

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Detalhes bibliográficos
Main Authors: Solis, Mayra, Nakhaei, Peyman, Jalalirad, Mohammad, Lacoste, Judith, Douville, Renée, Arguello, Meztli, Zhao, Tiejun, Laughrea, Michael, Wainberg, Mark A., Hiscott, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020501/
https://ncbi.nlm.nih.gov/pubmed/21084468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01635-10
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