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Dominant-negative activity of an α(1B)-adrenergic receptor signal-inactivating point mutation

α(1)-adrenergic receptors (α(1)-ARs) are members of the G-protein-coupled receptor (GPCR) superfamily and activate inositol phosphate (IP) turnover. We show that glycine and asparagine mutations of Phe303 in transmembrane segment VI (TMVI) of the α(1B)-AR, a highly conserved residue in GPCRs, althou...

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Autors principals: Chen, Songhai, Lin, Fang, Xu, Ming, Hwa, John, Graham, Robert M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC302026/
https://ncbi.nlm.nih.gov/pubmed/10944109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.16.4265
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