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Dominant-negative activity of an α(1B)-adrenergic receptor signal-inactivating point mutation
α(1)-adrenergic receptors (α(1)-ARs) are members of the G-protein-coupled receptor (GPCR) superfamily and activate inositol phosphate (IP) turnover. We show that glycine and asparagine mutations of Phe303 in transmembrane segment VI (TMVI) of the α(1B)-AR, a highly conserved residue in GPCRs, althou...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC302026/ https://ncbi.nlm.nih.gov/pubmed/10944109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.16.4265 |
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