RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J

The evolutionarily conserved Notch signal transduction pathway regulates fundamental cellular processes during embryonic development and in the adult. Ligand binding induces presenilin-dependent cleavage of the receptor and a subsequent nuclear translocation of the Notch intracellular domain (NICD)....

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Main Authors: Wacker, Stephan Armin, Alvarado, Cristobal, von Wichert, Götz, Knippschild, Uwe, Wiedenmann, Jörg, Clauß, Karen, Nienhaus, Gerd Ulrich, Hameister, Horst, Baumann, Bernd, Borggrefe, Tilman, Knöchel, Walter, Oswald, Franz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020113/
https://ncbi.nlm.nih.gov/pubmed/21102556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.289
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