Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response

RIG-I is an intracellular RNA virus sensor that mediates a signaling pathway that triggers the alpha/beta interferon (IFN-α/β) immune defenses. However, the mechanism for regulation of RIG-I activity remains largely unknown. Here we show that RIG-I activity is regulated by phosphorylation and dephos...

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Bibliografiske detaljer
Main Authors: Sun, Zhiguo, Ren, Hongwei, Liu, Yan, Teeling, Jessica L., Gu, Jun
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Cellular Response to Infection
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020001/
https://ncbi.nlm.nih.gov/pubmed/21068236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01734-10
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