RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus

In the cytoplasm, the retinoic acid-inducible gene I (RIG-I) senses the RNA genomes of several RNA viruses. RIG-I binds to viral RNA, eliciting an antiviral response via the cellular adaptor MAVS. Crimean-Congo hemorrhagic fever virus (CCHFV), a negative-sense RNA virus with a 5′-monophosphorylated...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Spengler, Jessica R., Patel, Jenish R., Chakrabarti, Ayan K., Zivcec, Marko, García-Sastre, Adolfo, Spiropoulou, Christina F., Bergeron, Éric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580164/
https://ncbi.nlm.nih.gov/pubmed/26223644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01643-15
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