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Noncytotoxic Inhibition of Viral Infection through eIF4F-Independent Suppression of Translation by 4EGi-1

The eukaryotic initiation factor eIF4F recruits ribosomes to capped mRNAs while eIF2 mediates start codon recognition to initiate protein synthesis. Increasing interest in targeting translation to suppress tumor growth has led to the development of new classes of inhibitors, including 4EGi-1, which...

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Main Authors: McMahon, Robert, Zaborowska, Izabela, Walsh, Derek
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019991/
https://ncbi.nlm.nih.gov/pubmed/21068241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01873-10
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