The RNA Helicase eIF4A Is Required for Sapovirus Translation

The eukaryotic initiation factor 4A (eIF4A) is a DEAD box helicase that unwinds RNA structure in the 5′ untranslated region (UTR) of mRNAs. Here, we investigated the role of eIF4A in porcine sapovirus VPg-dependent translation. Using inhibitors and dominant-negative mutants, we found that eIF4A is r...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Hosmillo, Myra, Sweeney, Trevor R., Chaudhry, Yasmin, Leen, Eoin, Curry, Stephen, Goodfellow, Ian, Cho, Kyoung-Oh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Virus-Cell Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859703/
https://ncbi.nlm.nih.gov/pubmed/26937032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03174-15
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