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Phosphorylation of Tristetraprolin by MK2 Impairs AU-Rich Element mRNA Decay by Preventing Deadenylase Recruitment
mRNA turnover is a critical step in the control of gene expression. In mammalian cells, a subset of mRNAs regulated at the level of mRNA turnover contain destabilizing AU-rich elements (AREs) in their 3′ untranslated regions. These transcripts are bound by a suite of ARE-binding proteins (AUBPs) tha...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology (ASM)
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3019984/ https://ncbi.nlm.nih.gov/pubmed/21078877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00717-10 |
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