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MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

Stress granules (SGs) are dynamic cytoplasmic foci at which stalled translation initiation complexes accumulate in cells subjected to environmental stress. SG-associated proteins such as TIA-1, TIAR and HuR bind to AU-rich element (ARE)-containing mRNAs and control their translation and stability. H...

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Udgivet i:EMBO J
Principais autores: Stoecklin, Georg, Stubbs, Tiffany, Kedersha, Nancy, Wax, Stephen, Rigby, William FC, Blackwell, T Keith, Anderson, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381421/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15014438/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600163
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