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Effect of Factor H-Binding Protein Sequence Variation on Factor H Binding and Survival of Neisseria meningitidis in Human Blood

Binding of the complement inhibitor factor H (fH) to the surface of Neisseria meningitidis is critical for evasion of innate host defenses. The meningococcal vaccine candidate factor H-binding protein (fHbp) serves as an fH ligand. We prepared 16 recombinant fHbp natural sequence variants. By enzyme...

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Bibliografiske detaljer
Main Authors: Dunphy, Kathleen Y., Beernink, Peter T., Brogioni, Barbara, Granoff, Dan M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019890/
https://ncbi.nlm.nih.gov/pubmed/21041484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00849-10
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