Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload

The heterohexameric minichromosome maintenance protein complex (Mcm2-7) functions as the eukaryotic helicase during DNA replication. Mcm2-7 loads onto chromatin during early G1 phase but is not converted into an active helicase until much later during S phase. Hence, inactive Mcm complexes are presu...

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Main Authors: Kuipers, Marjorie A., Stasevich, Timothy J., Sasaki, Takayo, Wilson, Korey A., Hazelwood, Kristin L., McNally, James G., Davidson, Michael W., Gilbert, David M.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2011
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019549/
https://ncbi.nlm.nih.gov/pubmed/21220507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201007111
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