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Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload
The heterohexameric minichromosome maintenance protein complex (Mcm2-7) functions as the eukaryotic helicase during DNA replication. Mcm2-7 loads onto chromatin during early G1 phase but is not converted into an active helicase until much later during S phase. Hence, inactive Mcm complexes are presu...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3019549/ https://ncbi.nlm.nih.gov/pubmed/21220507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201007111 |
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