Top-down morphogenesis of colorectal tumors

One of the fundamental tenets of oncology is that tumors arise from stem cells. In the colon, stem cells are thought to reside at the base of crypts. In the early stages of tumorigenesis, however, dysplastic cells are routinely found at the luminal surface of the crypts whereas the cells at the base...

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Detalhes bibliográficos
Main Authors: Shih, Ie-Ming, Wang, Tian-Li, Traverso, Giovanni, Romans, Kathy, Hamilton, Stanley R., Ben-Sasson, Shmuel, Kinzler, Kenneth W., Vogelstein, Bert
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30191/
https://ncbi.nlm.nih.gov/pubmed/11226292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051629398
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