Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

Resistance to chemotherapy is a major cause of mortality in advanced cancer patients. In this study, digital karyotyping was used to search for genomic alterations in liver metastases that were clinically resistant to 5-fluorouracil (5-FU). In two of four patients, we identified amplification of an...

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Hauptverfasser: Wang, Tian-Li, Diaz, Luis A., Romans, Katharine, Bardelli, Alberto, Saha, Saurabh, Galizia, Gennaro, Choti, Michael, Donehower, Ross, Parmigiani, Giovanni, Shih, Ie-Ming, Iacobuzio-Donahue, Christine, Kinzler, Kenneth W., Vogelstein, Bert, Lengauer, Christoph, Velculescu, Victor E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC420348/
https://ncbi.nlm.nih.gov/pubmed/14970324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308716101
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