A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models

Difficulties of drug delivery across the blood–brain barrier (BBB) and failure to eliminate cancer stem cells (CSCs) are believed to be the major causes of tumor recurrences in children with medulloblastoma (MB). Seneca Valley virus-001 (SVV-001) is a naturally occurring oncolytic picornavirus that...

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Hlavní autoři: Yu, Litian, Baxter, Patricia A., Zhao, Xiumei, Liu, Zhigang, Wadhwa, Lalita, Zhang, Yujing, Su, Jack MF, Tan, Xiaojie, Yang, Jianhua, Adesina, Adekunle, Perlaky, Lazlo, Hurwitz, Mary, Idamakanti, Neeraja, Police, Seshidhar Reddy, Hallenbeck, Paul L., Blaney, Susan M., Chintagumpala, Murali, Hurwitz, Richard L., Li, Xiao-Nan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018906/
https://ncbi.nlm.nih.gov/pubmed/21075780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq148
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