A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models

Difficulties of drug delivery across the blood–brain barrier (BBB) and failure to eliminate cancer stem cells (CSCs) are believed to be the major causes of tumor recurrences in children with medulloblastoma (MB). Seneca Valley virus-001 (SVV-001) is a naturally occurring oncolytic picornavirus that...

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Hauptverfasser: Yu, Litian, Baxter, Patricia A., Zhao, Xiumei, Liu, Zhigang, Wadhwa, Lalita, Zhang, Yujing, Su, Jack MF, Tan, Xiaojie, Yang, Jianhua, Adesina, Adekunle, Perlaky, Lazlo, Hurwitz, Mary, Idamakanti, Neeraja, Police, Seshidhar Reddy, Hallenbeck, Paul L., Blaney, Susan M., Chintagumpala, Murali, Hurwitz, Richard L., Li, Xiao-Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018906/
https://ncbi.nlm.nih.gov/pubmed/21075780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq148
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