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Translesion Synthesis Across Abasic Lesions by Human B-family and Y-family DNA Polymerases α, δ, η, ι, κ, and REV1

Abasic (AP) sites are the most common DNA lesions formed in cells, induce severe blocks to DNA replication, and are highly mutagenic. Human Y-family translesion DNA polymerases (pols) such as pols η, ι, κ, and REV1 have been suggested to play roles in replicative bypass across many DNA lesions where...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Choi, Jeong-Yun, Lim, Seonhee, Kim, Eun-Jin, Jo, Ara, Guengerich, F. Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018708/
https://ncbi.nlm.nih.gov/pubmed/20888339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.015
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