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Donor P-gp polymorphisms strongly influence renal function and graft loss in a cohort of renal transplant recipients on cyclosporine therapy in a long-term follow-up
Cyclosporine A (CsA) is a substrate for cytochrome P450 3A and the efflux transporter P-glycoprotein (P-gp; ABCB1), both abundantly expressed in the kidney. We retrospectively investigated the role of polymorphisms in CYP3A4, CYP3A5 and ABCB1 kidney graft donors on recipient renal function and subse...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Pub. Group
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017780/ https://ncbi.nlm.nih.gov/pubmed/20505666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2010.62 |
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