Donor P-gp polymorphisms strongly influence renal function and graft loss in a cohort of renal transplant recipients on cyclosporine therapy in a long-term follow-up

Cyclosporine A (CsA) is a substrate for cytochrome P450 3A and the efflux transporter P-glycoprotein (P-gp; ABCB1), both abundantly expressed in the kidney. We retrospectively investigated the role of polymorphisms in CYP3A4, CYP3A5 and ABCB1 kidney graft donors on recipient renal function and subse...

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Main Authors: Woillard, Jean-Baptiste, Rerolle, Jean-Philippe, Picard, Nicolas, Rousseau, Annick, Guillaudeau, A., Munteanu, Etienne, Essig, Marie, Drouet, M., Le Meur, Yann, Marquet, Pierre
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017780/
https://ncbi.nlm.nih.gov/pubmed/20505666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2010.62
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